A wounded Nathan Drake is waking up to find himself in a train hanging off a cliff. Through flashbacks, it is revealed that former associate Harry Flynn and old girlfriend Chloe Frazer approached him with a job offer to steal a Mongolian oil lamp in an Istanbul museum.

Among Thieves revolves around the doomed voyage home of Marco Polo from China in 1292. After spending almost 20 years in the court of the Mongol Emperor Kublai Khan, Marco Polo departed with fourteen ships and over six hundred passengers – but when he arrived at Persia a year and a half later, only one ship and eighteen passengers remained. Polo never revealed what had happened to the lost ships.