Just Cause is an army game which begins with Rico Rodriguez, an operative for an organization known as the Agency, being dropped into a Caribbean tropical island called San Esperito, after being called there by his commanding officer, Tom Sheldon, to help overthrow San Esperito’s dictator; Salvador Mendoza, whom the Agency believes to be in possession of weapons of mass destruction.

On the fictional island of Panau in Southeast Asia. Panau has varied terrain, from desert to alpine to rainforest. Rico Rodriguez returns as the protagonist, aiming to overthrow the evil dictator Pandak “Baby” Panay and confront his former mentor, Tom Sheldon.

Set several years after the events of Just Cause 2, Rico Rodriguez leaves The Agency and returns to his homeland of Medici, a fictional Mediterranean island under the brutal control of dictator General Di Ravello who has set his eyes on world domination.