As a first-person shooter, the gameplay of Duke Nukem 3D involves moving through levels presented from the protagonist’s point of view, shooting enemies on the way.

Duke is now a worldwide icon, and has achieved great fame from his heroic deeds. After sampling a video game based on his past heroics (the game Duke plays is a revamped version of the final level of the third episode of Duke Nukem 3D), he arrives on the set of a talk show for an interview.